Click here for full publication list:

http://www.ncbi.nlm.nih.gov/sites/myncbi/1x_1qnj-UwFQj/bibliography/48363118/public/?sort=date&direction=ascending

LinkedIn:

https://www.linkedin.com/in/radek-dobrowolski-a3656a48

Research Gate:

https://www.researchgate.net/profile/Radek_Dobrowolski

Selected Publications

  1. Khayati, K., Antikainen, H., Bonder, E.M., Weber, G.F., Jakubowski, H. & Dobrowolski, R. (2017). The Amino Acid Metabolite Homocysteine Activates mTORC1 to Inhibit Autophagy and Form Abnormal Proteins in Human Neurons and Mice. FASEB J. in print doi: 10.1096/fj.201600915R
  2. Reddy, K., Cusack, C.L., Nnah, I., Khayati, K., Saqcena, C. Huynh, T.B., Noggle, S., Ballabio, A. & Dobrowolski, R. (2016). Dysregulation of Nutrient Sensing and CLEARance in Presenilin Deficiency. Cell Reports 14:2166-2179.
  3. Das, S., Yu, S., Sakamori, R., Vedula, P., Feng, Q., Flores, J., Hoffman, A., Fu, J., Stypulkowski, E., Rodriguez, A., Dobrowolski, R., Harada, A., Hsu, W., Bonder, E.M., Verzi, M.P. & Gao, N. (2015). Rab8a vesicles regulate Wnt ligand delivery and Paneth cell maturation at intestinal stem cell niche. Development 142:2147-62.
  4. Nnah, I., Khayati, K. & Dobrowolski, R. (2015). Cellular metabolism and lysosomal mTOR signaling. Cell Death in Therapy, DeGruyterOpen 02:2015
  5. Lübkemeier, I., Requardt, R.P., Lin, X., Sasse, P., Andrié, R., Schrickel, J.W., Chkourko, H., Bukauskas, F.F., Kim, J.S., Frank, M., Malan, D., Zhang, J., Wirth, A., Dobrowolski, R., Mohler, P.J., Offermanns, S., Fleischmann, B.K., Delmar, M. & Willecke, K. (2013). Deletion of the last five C-terminal amino acid residues of connexin43 leads to lethal ventricular arrhythmias in mice without affecting coupling via gap junction channels. Basic Res. Cardiol. 108:348.
  6. Lübkemeier, I., Andrié, R., Lickfett, L., Bosen, F., Stöckigt, F., Dobrowolski, R., Draffehn, A.M., Fregeac, J., Schultze, J.L., Bukauskas, F.F., Schrickel, J.W. & Willecke, K. (2013). The Connexin40A96S mutation from a patient with atrial fibrillation causes decreased atrial conduction velocities and sustained episodes of induced atrial fibrillation in mice. J. Mol. Cell. Cardiol. 65:19-32.
  7. Dobrowolski, R.*, Vick, P.*, Ploper, D., Gumper, I., Snitkin, H., Sabatini, D.D. & De Robertis, E.M. (2012). Presenilin deficiency or lysosomal inhibition enhance Wnt signaling through relocalization of GSK3 to the late endosomal compartment. Cell Reports 5:1316-1328.
  8. Torres, A., Xu, Q., Wang, F., Fujita, T., Dobrowolski, R., Willecke, K., Takano, T., & Nedergaard, M.  Extracellular Ca2+ Acts as a Mediator of Communication from Neurons to Glia. (2012). Science Signal. 5:ra8. doi: 10.1126/ scisignal.2002160
  9. Dobrowolski, R. & De Robertis, E.M. Endocytic control of growth factor signalling: multivesicular bodies as signalling organelles. (2012). Nature Rev. Mol. Cell. Biol. 13:53-60.
  10. Frank, M., Wirth, A., Andri Eacute, R.E., Segschneider, S., Kreuzberg, M.M., Dobrowolski, R., Seifert, G., Offermanns, S., Nickenig, G., Willecke, K. & Schrickel, J.W. (2012). Connexin45 Provides Optimal AV-Nodal Conduction in the Adult Mouse Heart. Circ. Res. 111:1528-38.
  11. Degen, J., Dublin, P., Zhang, J., Dobrowolski, R., Jokwitz, M., Karram, K., Trotter, J., Jabs, R., Willecke, K., Steinhäuser, C. & Theis, M. (2012). Dual reporter approaches for identification of Cre efficacy and astrocyte heterogeneity. FASEB. J. 26:4576-4583.
  12. Lübkemeier, I., Machura, K., Kurtz, L., Neubauer, B., Dobrowolski, R., Schweda, F., Wagner, C., Willecke, K., & Kurtz, A. (2011). The connexin 40 A96S mutation causes renin-dependent hypertension. J. Am. Soc. Nephrol. 22:1031-1040.
  13. Taelman, V.F.*, Dobrowolski, R.*, Plouhinec, J.L., Fuentealba, L.C., Vorwald, P.P., Gumper, I., Sabatini, D.D. & De Robertis, E.M. (2010). Wnt Signaling Requires the Sequestration of Glycogen Synthase Kinase 3 inside Multivesicular Endosomes. Cell. 143:1136-48.**
  14. Frank, M., Eiberger, B., Janssen-Bienhold, U., Perez de Sevilla Mueller, L., Tjarks, A., Kim, J.S., Maschke, S., Dobrowolski, R., Sasse, P., Weiler, R., Fleischmann, B., & Willecke, K. (2010). Neuronal connexin36 can functionally replace connexin45 in mouse retina but not in the developing heart. J. Cell. Sci. 123:3605-3615.
  15. Dobrowolski, R., Hertig, G., Lechner, H., Wörsdörfer, P., Wulf, V., Dicke, N., Eckert, D., Bauer, R., Schorle, H. & Willecke, K. (2009). Loss of connexin43-mediated gap junctional coupling in the mesenchyme of limb buds leads to altered expression of morphogens in mice. Hum. Mol. Genet. 18:2899-2911.
  16. Auth, T., Schlüter, S., Urschel, S., Kussmann, P., Sonntag, S., Höher, T., Kreuzberg, M.M., Dobrowolski, R. & Willecke, K. (2009). The TSG101 protein binds to connexins and is involved in connexin degradation. Exp. Cell. Res. 315:1053-1062.
  17. Malan, D., Reppel, M., Dobrowolski, R., Roell, W., Smyth, N., Hescheler, J., Paulsson, M., Bloch, W. & Fleischmann, B.K. (2009). Lack of laminin gamma1 in embryonic stem cell-derived cardiomyocytes causes inhomogeneous electrical spreading despite intact differentiation and function. Stem Cells. 27:88-99.
  18. Dobrowolski, R. & Willecke, K. (2009). Connexin-caused genetic diseases and corresponding mouse models.  Antioxid. Redox. Signal. 11:283-295. Review.
  19. Dobrowolski, R., Sasse, P., Schrickel, J.W., Watkins, M., Kim, J.S., Rackauskas, M., Troatz, C., Ghanem, A., Tiemann, K., Degen, J., Bukauskas, F.F., Civitelli, R., Lewalter, T., Fleischmann, B.K. & Willecke, K. (2008). The conditional connexin43G138R mouse mutant represents a new model of hereditary oculodentodigital dysplasia in humans. Hum. Mol. Genet. 17:539-554.
  20. Dobrowolski, R.*, Sommershof, A*, and Willecke, K. (2007). Some oculodentodigital dysplasia-associated Cx43 mutations cause increased hemichannel activity in addition to deficient gap junction channels. J. Membr. Biol. 219:9-17
  21. Schnichels, M., Wörsdörfer, P., Dobrowolski, R., Markopoulos, C., Kretz, M., Schwarz, G., Winterhager, E. & Willecke, K. (2007). The connexin31 F137L mutant mouse as a model for the human skin disease erythrokeratodermia variabilis (EKV). Hum. Mol. Genet. 16:1216-1224.

*  Equal author contribution

** Faculty of 1000/Must read

 

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netobjects-236~sr_8462

Nnah, Khayati & Dobrowolski, 2015

Reddy et al., 2016

netobjects-236~sr_8462

Khayati et al., 2017

Dobrowolski Lab

Federated Department of Biological Sciences

Rutgers University-Newark and  New Jersey Institute of Technology

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