publication

The group's recent work on intestinal stem cell homeostasis, epithelial-microbial interaction, and colorectal cancer.

More

event

Academic and professional activities: research conference, lecture, presentation, thesis work, graduation, and teaching.

More

laboratory

Current team members, laboratory alumni, research interests, academic training, career development, and member contact info.

More

project

Research activities in intestinal stem cell development, maintanence, response to environment, and pathogenesis.

More
Featured event

jbc in press

October 10, 8:58 AM

Yu et al. Global Ablation of Mouse Rab11a Impairs Early Embryogenesis and Matrix Metalloproteinase Secretion. Using a Rab11a null mouse allele, the transport of multiple membrane-associated and soluble cargos was analyzed in mouse blastocysts and MEFs. Conclusion: Rab11a ablation impairs mouse blastocyst development and the secretion of soluble matrix metalloproteinases. Significance: In vivo functions of Rab11a in mouse fetal development and soluble MMP secretion were uncovered.

 

Cancer research, paper in press

August 28, 10:58 AM

Sakamori R et al., CDC42 inhibition suppresses progression of incipient intestinal tumors. Our results suggest that early-stage mutant intestinal epithelial cells must recruit the pleiotropic functions of Cdc42 for malignant progression, suggesting its relevance as a biomarker and therapeutic target for selective CRC intervention.

Latest news
22oct

j. cell physiol., in press

Feng et al., Keeping Wnt Signalosome in Control by Vesicular Traffic

10oct

yu et al, JBC, in press

Global Ablation of Mouse Rab11a Impairs Early Embryogenesis and Matrix Metalloproteinase Secretion.
11aug

cancer res., in press

Sakamori et al., CDC42 inhibition suppresses progression of incipient intestinal tumors.
24jul

embo j, in press

Yu et al., TLR sorting by Rab11 endosomes maintains intestinal epithelial-microbial homeostasis.
Twitter feed
Quick contact
Contact form submitted! We will be in touch soon.