The group's recent work on intestinal stem cell homeostasis, epithelial-microbial interaction, and colorectal cancer.More
Academic and professional activities: research conference, lecture, presentation, thesis work, graduation, and teaching.More
Current team members, laboratory alumni, research interests, academic training, career development, and member contact info.More
Research activities in intestinal stem cell development, maintanence, response to environment, and pathogenesis.More
jbc in pressOctober 10, 8:58 AM
Yu et al. Global Ablation of Mouse Rab11a Impairs Early Embryogenesis and Matrix Metalloproteinase Secretion. Using a Rab11a null mouse allele, the transport of multiple membrane-associated and soluble cargos was analyzed in mouse blastocysts and MEFs. Conclusion: Rab11a ablation impairs mouse blastocyst development and the secretion of soluble matrix metalloproteinases. Significance: In vivo functions of Rab11a in mouse fetal development and soluble MMP secretion were uncovered.
Cancer research, paper in pressAugust 28, 10:58 AM
Sakamori R et al., CDC42 inhibition suppresses progression of incipient intestinal tumors. Our results suggest that early-stage mutant intestinal epithelial cells must recruit the pleiotropic functions of Cdc42 for malignant progression, suggesting its relevance as a biomarker and therapeutic target for selective CRC intervention.
Das et al., Rab8a vesicles regulate Wnt ligand delivery and Paneth cell maturation at intestinal stem cell niche.
Feng et al., Keeping Wnt Signalosome in Control by Vesicular Traffic.